Simultaneous measurement of allantoin and urate in plasma: analytical evaluation and potential clinical application in oxidant:antioxidant balance studies.

نویسندگان

  • I F Benzie
  • W y Chung
  • B Tomlinson
چکیده

pharmacological basis of therapeutics, 9th ed. New York: McGraw-Hill, 1996:1311–40. 7. Henderson PA, Hillman RS. Characteristics of iron dextran utilization in man. Blood 1969;34:357–75. 8. American Regent Laboratories. Dexferrum, iron dextran injection, USP. Package insert. Shirley, NY: American Regent Laboratories, 1996. 9. Nissenson AR, Lindsay RM, Swan S, Seligman PA, Strobos J. Sodium ferric gluconate complex in sucrose is safe and effective in hemodialysis patients: North American trial. Am J Kidney Dis 1999;33:471–82. 10. Persijn JP, Van Der Slik W, Riethorst A. Determination of serum iron and latent iron-binding capacity (LIBC). Clin Chim Acta 1971;35:91–8. 11. Fairbanks VF, Klee GG. Biochemical aspects of hematology. In: Tietz NW, ed. Textbook of clinical chemistry. Philadelphia, PA: WB Saunders, 1986:1578– 82. 12. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. J Lab Clin Med 1988;111:566–70.

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Allantoin in human plasma, serum, and nasal-lining fluids as a biomarker of oxidative stress: avoiding artifacts and establishing real in vivo concentrations.

Urate is the terminal product of purine metabolism in primates, including humans. Urate is also an efficient scavenger of oxidizing species and is thought to be an important antioxidant in human body fluids. Allantoin, the major oxidation product of urate, has been suggested as a candidate biomarker of oxidative stress because it is not produced metabolically. Although urate is converted to all...

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عنوان ژورنال:
  • Clinical chemistry

دوره 45 6 Pt 1  شماره 

صفحات  -

تاریخ انتشار 1999